Screening of Gastric Antiulcer Activity of Sida cordifolia

Ulcers were introduced in 36 hrs fasted albino rats of either sex by aspirin plus pylorus ligation, aspirin, and ethanol treatment. Each induction model had four groups namely control, test and standard. In each model of ulcer induction, group that was pre dosed with the ethanolic extract of leaves of Sida cordifolia showed a considerable degree of antiulcer activity in comparison to positive controlled treated group. The antiulcer activity was appraised by determining and comparing the ulcer index in the test drug groups with that of the control group as well as Famotidine (20mg/kg) was used as reference drug. The results revealed significant antiulcer activity by reducing the ulcer index in the above model. The results obtained were verified with one way ANOVA followed by Schiff’s (multiple range test) and found to be significant at